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Sommaires des Revues - New England Journal of Medecine

The New England Journal of Medicine: Search Results in Neurology\Neurosurgery


The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology\Neurosurgery. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.


Case 35-2017: A 57-Year-Old Woman with Hypoesthesia and Weakness in the Legs and Arms  Voir?

Presentation of Case. Dr. Daniel B. Rubin (Neurology): A 57-year-old-woman was admitted to this hospital because of progressive hypoesthesia, paresthesia, and weakness in the arms and legs. The patient had been in her usual health until 18 months before this admission, when paresthesia developed in…

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An Unusual Cause of Leg Pain  Voir?

A 67-year-old woman presented to her primary care physician with pain in her legs. Approximately 7 weeks earlier, she had noticed a cramping sensation in the back of both thighs and both calves that occurred after walking a couple of blocks and was relieved with rest. . . .
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Lomustine and Bevacizumab in Progressive Glioblastoma  Voir?

No standard of care has been established for patients with progressive glioblastoma. Previous studies suggested that bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor, is safe and produces responses that result in a decreased use of glucocorticoids and increased…

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Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct  Voir?

Previous randomized trials that involved patients with acute stroke showed that endovascular thrombectomy had a clinical benefit when it was performed within 6 hours after the onset of stroke symptoms and that the benefit diminished as the interval between the time that the patient was last known…

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A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke  Voir?

Two years ago, the publication of the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), which investigated endovascular mechanical thrombectomy for the treatment of acute ischemic stroke, was called "a first step in the…

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Case 34-2017: A 76-Year-Old Man with Fever, Weight Loss, and Weakness  Voir?

Presentation of Case. Dr. Benjamin R. Robbins (Psychiatry): A 76-year-old man was admitted to this hospital in the late summer because of weight loss, generalized weakness, and fever. The patient had been well until 3 weeks before admission, when he began to have decreased energy and poor appetite,…

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Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy  Voir?

Spinal muscular atrophy (SMA) is a severe childhood monogenic disease resulting from loss or dysfunction of the gene encoding survival motor neuron 1 (SMN1). The incidence of this disease is approximately 1 in 10,000 live births, with a carrier frequency of 1 in 54. SMA is characterized by the…

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Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI  Voir?

Microgravity during spaceflight occurs when the force of gravity is unbalanced and the net force becomes so weak that virtual weightlessness results. The effects of microgravity on the brain have received attention in relation to a syndrome involving optic-disk edema and elevated intracranial…

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Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy  Voir?

Spinal muscular atrophy is an autosomal recessive neuromuscular disorder that is characterized by progressive muscle atrophy and weakness, with an estimated incidence of 1 in 11,000 live births. Approximately 60% of infants who are born with spinal muscular atrophy have type 1 disease, which is…

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The Dilemma of Two Innovative Therapies for Spinal Muscular Atrophy  Voir?

If you have made a diagnosis of spinal muscular atrophy (SMA) type 1 (also known as Werdnig–Hoffman disease) in a child, then you have vivid memories of informing desperate parents that there is nothing you can do for their child. Two innovative therapies for SMA may now bring some hope — but what…

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Surgery for Drug-Resistant Epilepsy in Children  Voir?

Children and adolescents with drug-resistant epilepsy are at increased risk for poor long-term intellectual and psychosocial outcomes, along with a poor health-related quality of life. In this form of recalcitrant epilepsy, appropriate surgical management is often undertaken with the goal of…

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Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy  Voir?

Adrenoleukodystrophy is an X-linked genetic disease that is caused by a defect in the gene ABCD1 (ATP-binding cassette, subfamily D, member 1), which encodes the peroxisomal ABC half-transporter ALD protein. Mutations in ABCD1 result in abnormal breakdown of very-long-chain fatty acids, a process…

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Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery  Voir?

In 2015, the World Health Organization (WHO) recognized epilepsy as a serious public health concern. Approximately 50 million people worldwide currently have epilepsy, and more than 30% of patients with epilepsy have inadequate seizure control with drug therapy. Epilepsy surgery is appropriate for…

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Officer of the Law  Voir?

"I blacked out driving the other day," my patient said. "Just for a few seconds, in a parking lot, and I’ve been fine ever since." Her neurologic deficits had almost resolved, and I had been ready to send her home. It was a busy night in the emergency department (ED). I had many patients to see,…

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Optimizing Treatment for Cerebral Adrenoleukodystrophy in the Era of Gene Therapy  Voir?

Adrenoleukodystrophy is a peroxisomal metabolic disorder that can be manifested by rapidly progressive cerebral demyelination (known as cerebral adrenoleukodystrophy) in affected boys and men. Untreated cerebral adrenoleukodystrophy causes severe disability or death approximately 2 years after its…

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The Success of Sinister Right-Handers in Baseball  Voir?

To the Editor: Left-handed people possess less hemispheric lateralization than right-handers, meaning that there is generally less differentiation between the functions of the right and left hemispheres of the brain. In a letter published in the Journal in 1982, McLean and Ciurczak claimed that in…

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Case 32-2017: A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats  Voir?

Presentation of Case. Dr. Amulya Nagarur: A 64-year-old man was evaluated in the emergency department of this hospital because of dyspnea, wheezing, headaches, cough, and night sweats. Approximately 6 years before this presentation, the patient had received a diagnosis of fibromyalgia, which had…

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Incidental Findings on Brain Imaging in the General Pediatric Population  Voir?

To the Editor: Incidentally discovered findings on brain magnetic resonance imaging (MRI) in healthy persons pose medical and ethical considerations regarding management. The prevalence of incidental findings on brain MRI has been described in adult populations, but less is known about incidental…

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Delirium in Hospitalized Older Adults  Voir?

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 75-year-old…

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Case 31-2017: A 19-Month-Old Girl with Failure to Thrive  Voir?

Presentation of Case. Dr. Rachelle E. Gupta (Pediatrics): A 19-month-old girl was admitted to this hospital because of failure to thrive. The patient had been born in Puerto Rico by induced vaginal delivery after 41 weeks of gestation. Her mother did not smoke, drink alcohol, or take any…
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Dernière mise à jour : 22/11/2017 : 01:58


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